How Long Does Lexapro Stay in Your System?

Lexapro, also known as escitalopram, is a commonly prescribed medication for the treatment of depression and anxiety disorders. It belongs to the class of selective serotonin reuptake inhibitors (SSRIs). Once the medication is consumed, it is absorbed quickly into the bloodstream, and its effects can last for several hours.

However, the duration of the effects of Lexapro varies from person to person, depending on several factors, including age, weight, metabolism, dosage, and length of treatment. In this blog post, we will go in-depth about how long Lexapro stays in the system, what factors affect its elimination, and how to manage any potential side effects.

How Long Does Lexapro Stay in Your System?

Lexapro has a relatively long half-life, which means that it takes a while for the drug to be eliminated from the body. The half-life of Lexapro is around 27-32 hours, meaning that it takes around five to six days for the medication to be cleared completely from the body. This is why Lexapro is typically taken once a day, and changing the dosage or stopping treatment should be done gradually over time to avoid withdrawal symptoms.

Factors Affecting the Elimination of Lexapro

Several factors affect how long it takes for Lexapro to be eliminated from the body. Some of these factors include:

1. Age: Older people tend to have slower metabolisms than younger people, which means that it may take longer for the medication to be processed and eliminated from their bodies.

2. Weight: People with higher body weights may require higher doses of medication, and it may take longer for the medication to be eliminated from their bodies.

3. Dosage: Higher doses of Lexapro take longer to be eliminated than lower doses.

4. Length of Treatment: Longer treatment periods result in the medication accumulating in the body, leading to a longer elimination time.

5. Metabolism: People with faster metabolisms tend to eliminate the medication quicker than those with slower metabolisms.

Managing Side Effects

Like all medications, Lexapro can cause side effects. Some of the most common side effects include dizziness, nausea, dry mouth, and sexual dysfunction. To manage these side effects, here are some tips:

1. Dizziness: Stand up slowly and avoid sudden movements.

2. Nausea: Take the medication with a meal or snack to reduce the chances of nausea.

3. Dry Mouth: Drink plenty of water and avoid drinks that can dehydrate you, such as alcohol and coffee.

4. Sexual Dysfunction: Speak to your doctor about adjusting your dosage, switching to a different medication, or using other interventions to help manage this side effect.


In conclusion, Lexapro is a widely used SSRI that is effective in treating depression and anxiety disorders. The duration of its effects varies from person to person, depending on several factors such as age, weight, metabolism, and dosage. It is important to follow your doctor’s instructions regarding dosage and treatment duration, and to speak with them if you experience any side effects that interfere with your daily life. Overall, understanding how long Lexapro stays in your system and how to manage potential side effects will help you make informed decisions about your medication regimen.

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